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Medchemexpress LLC Tezacaftor-d4 | 1961280-24-9 | C26H23D4F3N2O6 | 500 UG
Supplier: Medchemexpress LLC HY15448S500UG
Tezacaftor-d4 (VX-661-d4) is a deuterium-labeled variant of Tezacaftor, an F508del CFTR corrector. It aids the CFTR protein in reaching the cell surface and is valuable as a tracer and internal standard for quantitative analysis, particularly in drug development. Its deuterium incorporation can influence pharmacokinetic and metabolic profiles. When combined with Ivacaftor, Tezacaftor exhibits significant efficacy against cystic fibrosis and related conditions with the homozygous CFTR Phe508del mutation.
- Deuterium-labeled F508del CFTR corrector
- Assists CFTR protein trafficking to the cell surface
- Useful as a tracer and internal standard
- Incorporation of stable heavy isotopes for quantitation in drug development
- Potential to impact pharmacokinetic and metabolic profiles
- Potent efficacy against cystic fibrosis when combined with Ivacaftor
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