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Medchemexpress LLC TFMB-(R)-2-HG | 1445700-01-5 | 98.3% | 10 MG
SDP

Supplier:  Medchemexpress LLC HY12907910MG

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TFMB-(R)-2-HG is a cell membrane-permeable (R)-2-HG and an acute myeloid leukemia (AML) oncogenic factor. It functions by competitively inhibiting α-ketoglutarate-dependent dioxygenases, such as KDM2B and FTO. This compound impairs cell differentiation when there is estrogen withdrawal and is utilized in research concerning acute myeloid leukemia and glioma.

  • Promotes growth factor-independent growth of TF-1 cells and inhibits their response to erythropoietin (EPO) in a dose- and passage-dependent manner.
  • Significantly enhances anchorage-independent growth of N::TVA;Cdkn2alox/lox;Atrxlox/lox;Ptenlox/lox astrocytes.
  • Significantly suppresses global 5hmC levels in TF-1 cells and transforms TF-1 cells.
  • Inhibits the differentiation of SCF ER-Hoxb8 cells after estrogen withdrawal in mice.

Catalog No. 50-003-39433


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