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Medchemexpress LLC TFMU-ADPr diammonium | 2412923-11-4 | 98.8% | 805.50 | 1 MG
SDP

Catalog No. 5000359844
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TFMU-ADPr diammonium is a selective reporter substrate for SARS-CoV-2 Macro1, with excitation and emission wavelengths of 385 nm and 502 nm (or 495 nm) respectively. It undergoes enzymatic hydrolysis, releasing fluorophores to report total poly (ADP-ribose) hydrolase activity. This compound is valuable for evaluating small-molecule inhibitors targeting PAR hydrolases in vitro, investigating regulatory mechanisms of ADP-ribosyl catabolic enzymes, and detecting PAR hydrolase activity in whole-cell lysate assays, making it applicable to COVID-19-related research.

  • Functions as a continuous fluorescent substrate for hPARG, ttPARG, and hARH3
  • Potently binds to SARS-CoV-2 Macro1, human MacroD1, human MacroD2, VEEV Macro, and human PARP9 Macro2
  • Acts as an inhibitor of ADPr hydrolase activity

Catalog No. 50-003-59844 Supplier Medchemexpress LLC Supplier No. HY146248B1MG
May include imposed supplier surcharges.
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TFMU-ADPr diammonium is a selective reporter substrate for SARS-CoV-2 Macro1, with excitation and emission wavelengths of 385 nm and 502 nm (or 495 nm) respectively. It undergoes enzymatic hydrolysis, releasing fluorophores to report total poly (ADP-ribose) hydrolase activity. This compound is valuable for evaluating small-molecule inhibitors targeting PAR hydrolases in vitro, investigating regulatory mechanisms of ADP-ribosyl catabolic enzymes, and detecting PAR hydrolase activity in whole-cell lysate assays, making it applicable to COVID-19-related research.

  • Functions as a continuous fluorescent substrate for hPARG, ttPARG, and hARH3
  • Potently binds to SARS-CoV-2 Macro1, human MacroD1, human MacroD2, VEEV Macro, and human PARP9 Macro2
  • Acts as an inhibitor of ADPr hydrolase activity

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