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Apexbio Technology LLC TG100-115 677297-51-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A27545.1
TG100-115 (CAS 677297-51-7) is a selective inhibitor targeting phosphoinositide 3-kinase isoforms PI3K and PI3K with IC50 values of 83 nM and 235 nM respectively exhibiting negligible inhibition towards PI3K and PI3K Research in murine models demonstrates that treatment with TG100-115 significantly reduces eosinophil accumulation bronchoalveolar IL-13 cytokine levels mucus deposition and leukocyte infiltration associated with allergic asthma decreasing airway hyperresponsiveness by approximately 50% Moreover this compound attenuates neutrophil infiltration and TNF induction following exposure to cigarette smoke and LPS suggesting its utility as an investigational tool for asthma and inflammatory pulmonary diseases
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