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Apexbio Technology LLC TG101209 936091-14-4 200mg
SDP

Supplier:  Apexbio Technology LLC A4145200

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TG101209 (CAS 936091-14-4) is a structurally designed small molecule that functions as a selective inhibitor of Janus kinase 2 (JAK2) It inhibits the JAK/STAT signaling pathway particularly in cell lines harboring JAK2V617F or MPLW515L/K mutations commonly associated with polycythemia vera and primary myelofibrosis respectively In studies using multiple myeloma cell models TG101209 reduces the expression of phosphorylated JAK2 STAT3 and Bcl-xL while inducing overexpression of phosphorylated Erk and Akt This modulation of signaling pathways results in dose- and time-dependent cytotoxicity linked to cell cycle arrest and apoptosis supporting its utility in research on hematological malignancies driven by JAK2 dysregulation

Catalog No. 50-000-93577


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