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Genscript Corporation Antibody Protein Proteins Proteins 5 UG 1/EA
Supplier: Genscript Corporation Z031515
Protransforming Growth Factor-alpha (TGF-alpha) also known as sarcoma growth factor TGF-type I and ETGF is a member of the EGF family of cytokines. It is expressed in monocytes brain cells keratinocytes and various tumor cells. ProTGF-alpha signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. It may function as either a membrane-bound ligand or a soluble ligand. Membrane-bound proTGF-alpha plays a role in cell-cell adhesion and juxtacrine stimulation of adjacent cells. The soluble form of the cytokine is released from the membrane-bound form by proteolytic cleavage and acts as a mitogen for cell proliferation.
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