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Medchemexpress LLC TGF beta 1/TGFB1 LAP 50ug | 50ug
Supplier: Medchemexpress LLC HYP7816850UG
The latency-associated peptide (LAP) of the transforming growth factor -1 (TGF- -1) proprotein is an important precursor that forms a complex with TGF- -1 LAP maintains the latent state of TGF- -1 during storage in the extracellular matrix ensuring controlled activation Interactions with environmental molecules such as LTBP1 LRRC32/GARP and LRRC33/NRROS intricately regulate TGF- -1 activation LRRC33/NRROS influences the activation of macrophages and microglia while LRRC32/GARP controls the activation of activated regulatory T cells Interactions with integrins induce conformational changes in LAP releasing active TGF- -1 LAP orchestrates controlled TGF- -1 activation in different physiological contexts Recombinant human TGF beta 1/TGFB1 LAP (biotinylated expressed in HEK293 cells Avi-tagged) is a biotinylated Avi-tagged LAP protein expressed in HEK293 cells[1][2]
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