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Genscript Corporation Antibody Protein Proteins Proteins 1 MG 1/EA
Supplier: Genscript Corporation Z034321
Transforming growth factor beta 2 (TGF-beta 2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-beta 2 gene deletion show defects in development of cardiac lung craniofacial limb spinal column eye inner ear and urogenital systems. All TGF-beta isoforms signal via the same heteromeric receptor complex consisting of a ligand binding TGF-beta receptor type II (Tbeta R-II) and a TGF-beta receptor type I (Tbeta R-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-beta expression is found in cartilage bone teeth muscle heart blood vessels hematopoietic cells lung kidney gut liver eye ear skin and the nervous system.
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