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Cayman Chemical -ThalIdomIde 100mg
Supplier: Cayman Chemical 14610100 MG
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 UG/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 UG/kg egg weight)
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