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Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 1 G
Supplier: Medchemexpress LLC HY415471G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. Thalidomide targets cereblon (CRBN), a protein that is part of the cullin-4 E3 ubiquitin ligase complex, CUL4-RBX1-DDB1 (CRL4), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The product appears as an off-white to gray solid.
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to the ligand for IRAK4 protein to form PROTAC IRAK4 degrader-1
- Targets cereblon (CRBN), part of the CUL4-RBX1-DDB1 E3 ubiquitin ligase complex
- Mediates ubiquitination and proteasomal degradation of target proteins
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