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Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00078028 | 99.98% | 258.23 | 500 MG
Supplier: Medchemexpress LLC HY14658500MG
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of approximately 250 nM. It possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties. Thalidomide can also function as a molecular glue to potentiate substrate.
- Inhibits cereblon (CRBN), a component of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.
- Demonstrates immunomodulatory, anti-inflammatory, and anti-angiogenic properties.
- Functions as a molecular glue to potentiate substrate.
- Potentiates the anti-tumor activity of Icotinib against PC9 and A549 cell proliferation.
- Inhibits EGFR and VEGF-R2 pathways in PC9 cells.
- Alleviates RILF by suppressing ROS and down-regulating the TGF-β/Smad pathway.
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