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Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 10 MG
Supplier: Medchemexpress LLC HY10361110MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon ligand-linker conjugate (trifluoroacetic acid salt) designed as a building block for PROTAC synthesis. It links a thalidomide-derived E3 ligase ligand to a three-unit PEG spacer terminating in a C2 amino handle, enabling attachment to targeting ligands and facilitating cereblon-mediated target degradation.
- Thalidomide-based cereblon ligand for E3 ligase recruitment.
- Three-unit PEG linker providing flexible spacing and solubility.
- C2 amino terminal suitable for amide or urea coupling.
- Trifluoroacetic acid salt form for improved handling and stability.
- Molecular formula C25H31F3N4O11; molecular weight 620.53 g/mol.
- Soluble in DMSO at 50 mg/mL; ultrasonic may be required.
- Recommended storage: 4°C sealed; in solvent store at -80°C (6 months) or -20°C (1 month).
- Available in small research quantities suitable for synthesis, e.g., 10 mg.
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