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Medchemexpress LLC Thalidomide-o-amido-PEG4-azide | 2411681-89-3 | 99.2% | C25H32N6O10 | 25 MG
Supplier: Medchemexpress LLC 25MGHY141011
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. This compound also functions as a versatile click chemistry reagent due to its azide group, enabling both copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with appropriate alkyne-containing molecules. PROTACs, which utilize this linker, are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Functions as a click chemistry reagent
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Exploits the ubiquitin-proteasome system
- Supports selective degradation of target proteins
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