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Medchemexpress LLC Thalidomide-PEG4-Propargyl | 2098799-77-8 | MFCD32207014 | >96.5% | 488.49 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1400551MG

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Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

  • PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
  • PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Catalog No. 50-003-49200


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