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Medchemexpress LLC Thalidomide-propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | 428.39 g/mol | C21H20N2O8 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1387775MG

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Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a PEG2 linker terminating in a propargyl carboxylic acid. It is intended for PROTAC construction and click-chemistry applications, providing an alkyne handle for downstream conjugation.

  • Contains terminal propargyl (alkyne) group for copper-catalyzed azide-alkyne cycloaddition.
  • Incorporates a PEG2 linker to improve solubility and provide appropriate spacer length.
  • Acts as a cereblon ligand to recruit CRBN for targeted protein degradation strategies.
  • High purity suitable for research and synthetic applications.
  • Available in small pack sizes for efficient use in medicinal chemistry workflows.

Catalog No. 50-002-22529


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