Thapsigargin, 95%

Description

CAS: 67526-95-8 | C34H50O12 | 650.76 g/mol

Thapsigargin- induces down regulation of the EGF receptor is independent of protein kinase C activation. It is also used as an inducer of stored Ca2+ release.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Thapsigargin- induces down regulation of the EGF receptor is independent of protein kinase C activation. It is also used as an inducer of stored Ca2+ release.

Solubility
Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), and acetone.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C.

Specifications

Chemical Identifiers

• CAS: 67526-95-8
• Molecular Formula: C34H50O12
• Molecular Weight (g/mol): 650.76
• MDL Number: MFCD00083511
• InChI Key: IXFPJGBNCFXKPI-FSIHEZPISA-N
• PubChem CID: 126969181
• SMILES: CCCCCCCC(=O)O[C@@H]1[C@@H](OC(=O)C(\C)=C/C)C(C)=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@H](C[C@](C)(OC(C)=O)[C@@H]12)OC(=O)CCC

• Color: White
• Quantity: 1 mg
• Sensitivity: Light sensitive
• Merck Index: 14,9272
• Synonym: thapsigargin, unii-z96bq26rzd, z96bq26rzd, chembl96926, octanoic acid 3s-3alpha, 3abeta, 4alpha, 6beta, 6abeta, 7beta, 8alpha z , 9balpha-6-acetyloxy-2,3,-3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-2-methyl-1-oxo-2-butenyl oxy-2-oxo-4-1-oxobutoxy-azuleno 4,5-b furan-7-yl ester, octanoic acid, 6-acetyloxy-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-2-methyl-1-oxo-2-butenyl oxy-2-oxo-4-1-oxobutoxy azuleno 4,5-b furan-7-yl ester, 3s-3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha z ,9balpha, tg1, --thapsigargin, octanoic acid 3s-3alpha, 3abeta, 4alpha, 6beta,6abeta, 7beta, 8alpha z , 9balpha-6-acetyloxy-2,3,-3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-2-methyl-1-oxo-2-butenyl oxy-2-oxo-4-1-oxobutoxy-azuleno 4,5-b furan-7-yl ester, octanoic acid 3s-3alpha, 3abeta, 4alpha,6beta, 6abeta, 7beta, 8alpha z , 9balpha-6-acetyloxy-2,3,-3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-2-methyl-1-oxo-2-butenyl oxy-2-oxo-4-1-oxobutoxy-azuleno 4,5-b furan-7-yl ester
• Solubility Information: Soluble in DMSO (20mg/ml),ethanol (20mg/ml),and acetone.
• IUPAC Name: [(3S,3aR,4S,6S,6aS,7S,8S,9bR)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-(2-methylbut-2-enoyloxy)-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
• Formula Weight: 650.75
• Percent Purity: 95%
• Physical Form: Solid Film
• Chemical Name or Material: Thapsigargin

Safety and Handling

Hazard Category	H315-H319-H334-H335
Hazard Statement	GHS H Statement H334-H335-H315-H319 May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation. Causes skin irritation. Causes serious eye irritation.
Precautionary Statement	P261-P264b-P271-P280-P285-P302+P352-P304+P340-P305+P351+P338-P332+P313-P342+P311-P362-P501c
RTECSNumber	RH0325700
TSCA	No
Recommended Storage	Store at -20°C; Store under Nitrogen

SDS

RUO – Research Use Only