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Bachem H-Gly-His-Arg-Pro-NH2
Supplier: Bachem 4075030.0025
H-Gly-His-Arg-Pro-NH2 Acetate, 209623-54-1, C19H32N10O4, Mr 464.53, 25mg. GHRP amide. The central E region of fibrin contains two sets of polymerization knobs, A and B, that are cryptic in fibrinogen but become exposed after thrombin cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB) from the N-terminus of the Aa- and Bb-chains, respectively. The location of the binding holes and possible models for knob-hole interactions are known from X-ray crystallographic studies using synthetic peptide analogs of knobs A and B. When fibrinogen fragment D and double-D are crystallized in the presence of both peptide analogs, the knob A peptide mimic H-Gly-Pro-Arg-Pro-NH2 (GPRP-amide) forms H-bond interactions with residues g364Asp, g330Asp, g329Gln, and g340His found in hole a. In the same manner, the knob B peptide mimic H-Gly-His-Arg-Pro-NH2 (GHRP-amide) interacts with residues Bb397Glu, Bb398Asp, and Bb432Asp in hole b.
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