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Bachem Boc-Arg-Val-Arg-Arg-AMC
Supplier: Bachem 4018735.0025
Boc-Arg-Val-Arg-Arg-AMC Acetate, 136132-77-9, C38H62N14O8, Mr 843.01, 25mg. The fluorogenic substrate Boc-RVRR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx. 4·103 M-1s-1). As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues. Boc-RVRR-AMC is also cleaved by proprotein convertase 4. Stock solutions of Boc-RVRR-AMC are best prepared in DMSO.
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