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Cayman Chemical thIo-p-ToluamIde 500mg
SDP

Supplier:  Cayman Chemical 13229500 MG

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An S1P2 and S1P4 receptor antagonist (IC50 17 and 237 nM respectively) selective for S1P2 over S1P1 and S1P3 (IC50s 10 UM for both) reverses S1P-induced inhibition of HUVEC and SMC migration at 1 and 10 UM reverses S1P-induced inhibition of B16 murine melanoma cell migration reduces lung injury endothelial dysfunction and pulmonary edema in a rat model of cecal ligation and puncture-induced sepsis at 30 mg/kg inhibits DES1 (IC50 16 8 UM) as well as SK1 and SK2 (IC50s 25 1 and 4 3 UM respectively)

Catalog No. 50-295-2698


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