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Cayman Chemical ThIoetheramIde-PC 10mg
Supplier: Cayman Chemical 6275010 MG
Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of sPLA2.{808,2624} The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.{808} In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.{808}
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