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Medchemexpress LLC Thiolutin | 87-11-6 | 25 MG
Supplier: Medchemexpress LLC 25MGHYN6712
Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic and a potent inhibitor of bacterial and yeast RNA polymerases. It acts as a dual inhibitor of BRCC36 and the NLRP3 inflammasome, demonstrating anti-inflammatory effects. It suppresses the interaction between BRCC36 and HMGCR, inhibiting HCC growth, attenuating pyroptosis and NLRP3 inflammasome activation, and alleviating renal injury and inflammatory processes. Thiolutin is also an anti-angiogenic compound that can ease Doxorubicin-induced cardiotoxicity (DOXIC).
- Potent inhibitor of bacterial and yeast RNA polymerases.
- Dual inhibitor of BRCC36 and the NLRP3 inflammasome.
- Exhibits anti-inflammatory properties and attenuates pyroptosis.
- Suppresses BRCC36 and HMGCR interaction, inhibiting HCC growth.
- Alleviates renal injury in IgAN and Doxorubicin-induced cardiotoxicity.
- Can be produced by Streptomyces.
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