Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Thiolutin (acetopyrrothin) | 87-11-6 | 1 ML
Supplier: Medchemexpress LLC HYN671210MM/1ML
Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic and a potent inhibitor of bacterial and yeast RNA polymerases. It is produced by Streptomyces. Thiolutin inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM). It acts as a dual inhibitor of BRCC36 and the NLRP3 inflammasome, demonstrating anti-inflammatory effects and effectively suppressing the interaction between BRCC36 and HMGCR, thereby inhibiting HCC growth.
- Potent inhibitor of bacterial and yeast RNA polymerases.
- Inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM).
- Dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects.
- Suppresses the interaction between BRCC36 and HMGCR, inhibiting HCC growth.
- Attenuates pyroptosis and NLRP3 inflammasome activation.
- Alleviates renal injury and inflammatory process in IgAN.
- Anti-angiogenic compound that can ease doxorubicin-induced cardiotoxicity (DOXIC).
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?