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Cayman Chemical ThIomyrIstoyl 50mg
Supplier: Cayman Chemical 1939850 MG
A potent and selective SIRT2 inhibitor (IC50s = 0.028, 98, >200, and >200 μM for SIRT2, SIRT1, SIRT3, and SIRT5-7, respectively); inhibits acetyl-H3K9 peptide and NAD binding to SIRT2 and promotes c-Myc degradation in a dose-dependent manner; exhibits selective cytotoxicity (IC50s = 8.4-36.8 and >50 μM for cancerous and non-cancerous cell lines, respectively); decreases tumor volume and increases areas of necrosis in an MDA-MB-231 mouse breast cancer xenograft model; increases tumor-free survival time in a MMTV-PyMT mouse mammary tumor model
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