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Medchemexpress LLC Thioridazine | 50-52-2 | MFCD00242875 | 99.5% | 200 MG
Supplier: Medchemexpress LLC HYB0965A200MG
Thioridazine is an antagonist of the dopamine receptor D2 family proteins, exhibiting potent anti-psychotic and anti-anxiety activities. It is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with an anti-angiogenic effect, showing antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity in targeting cancer stem cells (CSCs).
- Reduces cell viability of NCI-N87 and AGS cells
- Reduces cell viability of cervical and endometrial cancer cells
- Induces gastric cancer cell death via the mitochondrial apoptosis pathway
- Modulates cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest
- Inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii
- Extends the survival of tumor-bearing mice
- Reduces oral behavior and selectively blocks repetitive head bobbing
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