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Apexbio Technology LLC THIP hydrochloride 85118-33-8 10mM (in 1mL DMSO)

Supplier: Apexbio Technology LLC B64605.1
THIP hydrochloride (CAS 85118-33-8) is a small-molecule agonist of GABA receptors with primary activity in the central nervous system It selectively binds to GABAA receptor subtypes displaying affinity for 1 2 2 5 and 4 3 subunits In pharmacological studies THIP hydrochloride demonstrates subunit-specific efficacy with ED50 values of 143 M for 1 2 2 28 129 M for 5 and 6 M for 4 3 This compound is widely employed as a research tool in neuroscience to investigate GABAergic neurotransmission receptor pharmacology and explore potential therapeutic strategies related to neural modulation
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