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Medchemexpress LLC Thp-peg4-pyrrolidine(n-me)-ch2oh | 2378261-81-3 | 95.0% | 25 MG
Supplier: Medchemexpress LLC 25MGHY130821
THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins, typically consisting of two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein.
- Peg-based PROTAC linker.
- Used in the synthesis of PROTAC K-Ras degrader-1.
- Enables PROTACs to leverage the ubiquitin-proteasome system.
- PROTAC K-Ras degrader-1 shows ≥70% degradation efficacy in SW1573 cells.
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