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  7. threo Ifenprodil hemitartrate, Tocris Bioscience™

threo Ifenprodil hemitartrate, Tocris Bioscience™

Catalog No. 289210
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Catalog No. Quantity
28-9210 10 mg
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Description

GluN2B-selective NMDA antagonist; also σ agonist

Potent σ receptor agonist (Ki values are 59.1 and 2 nM for σ1 and σ2 receptors respectively) and GluN2B (formally NR2B) subunit-selective NMDA receptor antagonist (IC50 values are 0.22 and 324.8 μM at GluN2B and GluN2A respectively). Displays ∽8-fold reduced affinity at α-adrenoceptors compared to Ifenprodil (Cat.No. 0545). Inhibits the hERG potassium channel (IC50 = 88 nM) and exhibits antiarrhythmic activity in vivo.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Chemical Identifiers

CAS 1312991-83-5
Molecular Formula C92H120N4O20
Molecular Weight (g/mol) 1601.98
InChI Key MMUFFGLAKFWLGJ-RRQZTXAJSA-N
Synonym threo ifenprodil hemitartrate
PubChem CID 90488783
IUPAC Name 4-[(1S,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol;4-[(1R,2R)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol;2,3-dihydroxybutanedioic acid
SMILES CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O

Specifications

Quantity 10 mg
Formula Weight 400.49
Percent Purity >98%
Chemical Name or Material threo Ifenprodil hemitartrate

Safety and Handling

Recommended Storage Store at Room Temperature
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