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Cayman Chemical THUNDRTotal BTK TRFRET Ce 96

Supplier: Cayman Chemical 50024196 WELL

A P2X7 receptor antagonist (IC50 3.2 nM for the human receptor) inhibits LPS- and BzATP-induced increases in ROS levels in THP-1 macrophages at 1 UM decreases the accumulation of misfolded tau aggregates in the brain and improves learning and memory in the Y-maze and contextual fear conditioning tests in human P301S tau transgenic mice at 20 mg/kg twice per day reverses mechanical allodynia in a rat model of chronic constriction injury-induced allodynia at 20 mg/kg
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