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Cayman Chemical THUNDRTotal BTK TRFRET Ce 9600
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Supplier:  Cayman Chemical 5002419600 WELL

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An orexin receptor 2 agonist selectively induces calcium mobilization in CHO-K1 cells expressing human OX2R over those expressing OX1R (EC50s 0.019 and 14 UM respectively) selective for OX2R over a panel of 106 enzymes receptors and ion channels at 10 UM increases wakefulness time and wakefulness episode duration and inhibits chocolate-induced cataplexy-like episodes during the active phase in a model of narcolepsy using mice with orexin neurons ablated by ataxin-3 expression increases wakefulness time but does not affect OXA or OXB CSF levels during the sleep phase in cynomolgus monkeys at 10 mg/kg

Catalog No. 50-289-5965


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