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Cayman Chemical THUNDRTotal STAT5 TRFRET 4800

Supplier: Cayman Chemical 5002164800 WELL

An MCT4 inhibitor (IC50 1.3 nM) selectively inhibits lactate influx in NCI H358 cells (IC50 6.1 nM) which highly express MCT4 and do not express MCT1 over lactate influx in K562 cells (IC50 >30 UM) which highly express MCT1 and do not express MCT4 inhibits the proliferation of NCI H358 cells (IC50 26 nM) reduces tumor growth in an NCI H358 mouse xenograft model at 100 mg/kg twice per day in combination with cediranib
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