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ABclonal Technology Thymidylate synthase
SDP

Catalog No. 5000005506
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Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 10-methylenetetrahydrofolate (methylene-THF) as a cofactor This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair The enzyme has been of interest as a target for cancer chemotherapeutic agents It is considered to be the primary site of action for 5-fluorouracil 5-fluoro-2-prime-deoxyuridine and some folate analogs Expression of this gene and that of a naturally occurring antisense transcript mitochondrial enolase superfamily member 1 (GeneID 55556) vary inversely when cell-growth progresses from late-log to plateau phase Polymorphisms in this gene may be associated with etiology of neoplasia including breast cancer and response to chemotherapy

Catalog No. 50-000-05506 Supplier ABclonal Technology Supplier No. A2416820UL
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Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 10-methylenetetrahydrofolate (methylene-THF) as a cofactor This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair The enzyme has been of interest as a target for cancer chemotherapeutic agents It is considered to be the primary site of action for 5-fluorouracil 5-fluoro-2-prime-deoxyuridine and some folate analogs Expression of this gene and that of a naturally occurring antisense transcript mitochondrial enolase superfamily member 1 (GeneID 55556) vary inversely when cell-growth progresses from late-log to plateau phase Polymorphisms in this gene may be associated with etiology of neoplasia including breast cancer and response to chemotherapy

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