Cayman Chemical ThymohydroquInon 50mg

Supplier:  Cayman Chemical 2755850 MG

A sesquiterpene with diverse biological activities inhibits LPS-induced increases in TNF-a and NO production as well as iNOS activity in murine peritoneal macrophages (IC50s 23 1 41 and 67 3 M respectively) reduces pouch fluid w8 inflammatory cell count granuloma w8 and vascular index (ID50s 24 18 19 46 14 44 and 15 15 mg/kg respectively) in a mouse air pouch granuloma model induced by FCA reduces the number of microvessels in the air pouch wall by 58 27 at 20 mg/kg and reduces the blood levels of TNF-a IL-1B IL-6 VEGF PlGF and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma inhibits the growth of T-24 5637 RT4 and 253J bladder cancer cells in vitro (IC50s 12 8-63 7 M) reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner reverses stress-induced decreases in hippocampal levels of 5-HT and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner in a mouse

Catalog No. 50-294-1478