Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000062319

Apexbio Technology LLC THZ1 1604810-83-4 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A88825.1

Encompass_Preferred

THZ1 (CAS 1604810-83-4) is a covalent inhibitor of cyclin-dependent kinase 7 (CDK7) targeting specifically the cysteine residue C312 outside its kinase domain It exhibits potent inhibition with an IC50 of 3 2 nM against CDK7 in kinase binding assays In cellular studies THZ1 suppresses proliferation of Jurkat and Loucy T-cell acute lymphoblastic leukemia (T-ALL) cell lines (IC50 50 nM and 0 55 nM respectively) by disrupting CDK7-mediated signaling transcriptional regulation mediated by RUNX1 and RNA polymerase II CTD phosphorylation Thus THZ1 is utilized in cancer research to investigate transcriptional dysregulation in malignancies

Catalog No. 50-000-62319


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.