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AdipoGen TIE-2 human mAb tek2
Supplier: AdipoGen AG20T0102C100
Monoclonal Antibody. Native human TIE-2 in ELISA experiments and on the surface of different human cell types. Isotype Mouse IgG1. Clone tek2. Applications ELISA, FACS, WB. Lyophilized. TIE-2 acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. It has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. It is required for normal angiogenesis and heart development during embryogenesis and for post-natal hematopoiesis. After birth, it activates or inhibits angiogenesis, depending on the context. It inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts.
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