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Eurofins Discoverx Tie2 (R849W), active, 250 µg. (14-763M)
Supplier: Eurofins Discoverx 14763M
N-terminal 6xHis-tagged recombinant, human Tie2 amino acids 771-end containing the R849W substitution. The R849W mutation has been reported in dominantly inherited venous malformations. Expression studies in insect and mammalian cells demonstrates that Tie2 R849W has constitutively elevated tyrosine kinase activity compared with wild type. (Morris P.N., et al., Biochem. Biophys. Res. Commun.(2006);346:335-338 and Vikkula M, et al., Cell(1996);87:1181-1190). For detailed product information, visit www.discoverx.com/proteins.
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