TIGIT Detection Set, ProSci

Catalog No.	Quantity
16-595-252	1 Set

Catalog No. 16-595-252 Supplier ProSci LLC Supplier No. SD8800SET

Description

Llama Monoclonal Detection Sets

TIGIT Monoclonal specifically detects TIGIT in Human samples. It is validated for ELISA, IHC-P, ICC, IF, Flow

TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

Specifications

• Antigen: TIGIT
• Applications: ELISA, Immunohistochemistry (Paraffin), Immunocytochemistry, Immunofluorescence, Flow Cytometry
• Concentration: Antibody 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TIGIT Antibodies are supplied in PBS.
• Host Species: Llama
• Immunogen: TIGIT antibodies were raised against a recombinant protein corresponding to amino acids 22-141 of human TIGIT.
• Purification Method: TIGIT Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein. They also contains a myc-tag for detection.
• Quantity: 1 Set
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: TIGIT antibodies should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Product Type: Detection Sets
• Form: Liquid