TIGIT Detection Set (Risk Free), ProSci

Catalog No.	Quantity
16-595-554	1 Set

Catalog No. 16-595-554 Supplier ProSci LLC Supplier No. RF16050SET

Description

Mouse Monoclonal Detection Sets

TIGIT Monoclonal specifically detects TIGIT in Human samples. It is validated for ELISA, ICC, IHC-P, Flow, IF

The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2). ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications

Specifications

• Antigen: TIGIT
• Applications: ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Flow Cytometry, Immunofluorescence
• Concentration: Antibody 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS containing 0.02% sodium azide.
• Host Species: Mouse
• Immunogen: TIGIT antibodies were raised against the extracellular domain of human TIGIT.
• Purification Method: Antibodies are supplied as protein A purified IgG2b.
• Quantity: 1 Set
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Antibodies can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Product Type: Detection Sets
• Form: Liquid
• Isotype: IgG1, IgG2a, IgG2b