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AdipoGen Tim-3 (mouse):Fc (human) (rec.) (50 µg)
Supplier: AdipoGen AG40B0191C050
Recombinant protein. The extracellular domain of mouse Tim-3 (aa 21-189) is fused to the N-terminus of the Fc region of human IgG1. Produced in HEK 293 cells. Endotoxin: <0.01EU/µg purified protein (LAL test). Lyophilized. Contains PBS. Purity: >95% (SDS-PAGE). The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3 is also activated by galectin-9, leading to T cells inhibition. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses.
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