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Cayman Chemical TInptInsodIum salt 50mg
SDP

Supplier:  Cayman Chemical 1756150 MG

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A piperazine derivative with cardioprotective activity reduces INa in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ ventricular myocytes isolated from a canine model of heart failure guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II and HEK293 cells expressing human Nav1.5 channels (IC50s 5.9-15 M) reduces IKr in canine ventricular myocytes and HEK293 cells (IC50s 11.5 and 14.4 M respectively) reduces clofilium-induced prolongation of the QTc interval and TdP in rabbits at 480 g/kg per min reduces interstitial collagen deposition as well as ANP CTGF BNP and MMP-2 mRNA levels and prevents left ventricular dilation in a mouse model of doxorubicin-induced cardiotoxicity

Catalog No. 50-298-0224


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