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Apexbio Technology LLC Tipifarnib (Zarnestra) 192185-72-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A42275.1
Tipifarnib (Zarnestra CAS 192185-72-1) is an orally bioavailable imidazole quinolinone derivative specifically designed as a non-peptidomimetic inhibitor of the enzyme farnesyltransferase (FTase) FTase catalyzes the farnesylation of proteins essential for tumor cell proliferation and survival By selectively blocking FTase activity Tipifarnib disrupts downstream signaling pathways suppressing cellular proliferation and inducing apoptosis across diverse cancer cell types notably acute myeloid leukemia (AML) and multiple myeloma (MM) In preclinical models Tipifarnib demonstrates antiproliferative and pro-apoptotic activities supporting its utility in targeted cancer therapy research
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