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Apexbio Technology LLC Tirofiban 144494-65-5 5mg
Supplier: Apexbio Technology LLC B20525
Tirofiban is a selective non-peptide antagonist targeting platelet glycoprotein (GP) IIb/IIIa receptors a heterodimeric complex abundantly expressed on platelet surfaces responsible for mediating fibrinogen binding and platelet aggregation It acts through competitive inhibition of fibrinogen binding at GP IIb/IIIa sites thereby suppressing platelet cross-linking and aggregation induced by agonists like ADP In vitro studies demonstrate that Tirofiban inhibits ADP-induced platelet aggregation with an IC50 value of approximately 9 nM showing significantly lower affinity for integrin v 3 (vitronectin receptor) Tirofiban is frequently applied in biomedical research investigating platelet aggregation mechanisms and thrombotic events
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