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Medchemexpress LLC Tisolagiline monomethylsulfate | 1894207-45-4 | 99.8% | 10 MG
Supplier: Medchemexpress LLC HY127109A10MG
Tisolagiline monomethylsulfate (KDS2010) is a selective, reversible, and orally active inhibitor for MAO-B with an IC50 of 8 nM. It exhibits neuroprotective and anti-neuroinflammatory activities. It reduces glial fibrillary acidic protein (GFAP) expression and glycosaminoglycan (CSPGs) deposition, thereby inhibiting astrocyte activation and scar formation.
- Ameliorates MPTP-induced Parkinson's disease in mouse models, alleviating motor dysfunction.
- Reverses reduction in TH-positive neurons and reduces GFAP and iNOS expression.
- Inhibits astrocyte scar formation.
- Increases doxorubicin penetration into glioblastoma domains and glioblastoma tumor volume in mouse models.
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