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Medchemexpress LLC Tisolagiline monomethylsulfate | 1894207-45-4 | 99.8% | 100 MG
Supplier: Medchemexpress LLC HY127109A100MG
Tisolagiline methylsulfate is a selective, reversible, and orally active inhibitor for MAO-B with an IC50 of 8 nM. It exhibits neuroprotective and anti-neuroinflammatory activities. This product is for research use only and is not sold to patients.
- IC50 & target: MAO-B: 8 nM (IC50)
- In vitro: At 1 μM for 4 days, it inhibits astrocyte activation and scar formation by reducing glial fibrillary acidic protein (GFAP) and glycosaminoglycans (CSPGs) expression.
- In vivo: In MPTP-induced Parkinson's disease mouse models, it ameliorates motor dysfunction and reduces GFAP/iNOS expression. In U87 MG xenograft models, it inhibits astrocyte scar formation, enhancing Doxorubicin penetration and increasing glioblastoma (GBM) tumor volume.
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