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Medchemexpress LLC Tivozanib hydrochloride hydrate | 682745-41-1 | 99.8% | 509.34 | 10 MM 1 ML
Supplier: Medchemexpress LLC HY10977A10MG
Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib. It is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2, and 3. This compound exhibits antitumor efficacy.
- Selective, orally active inhibitor for VEGFR-1, 2, and 3
- Exhibits antitumor efficacy
- Available in solid form, white to off-white color
- Soluble in DMSO (125 mg/mL)
- Inhibits the phosphorylation of VEGFR-1, VEGFR-2, and VEGFR-3
- Inhibits VEGF-induced proliferation and migration of HUVECs
- Selectively inhibits VEGF-stimulated phosphorylation of MAPKs in endothelial cells
- Exhibits antitumor efficacy against various cancers in athymic mice models
- Reversibly suppresses vascular permeability and angiogenesis in tumor-bearing rats
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