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Medchemexpress LLC TK-112690 | 22423-26-3 | 240.21 | 25 G
Supplier: Medchemexpress LLC 25GHYW008491
TK-112690 is a UPP1 inhibitor that increases plasma uridine concentration. It inhibits murine small intestinal uridine phosphorylase (UPase) with an IC50 of 12.5 μM and human small intestinal UPase with an IC50 of 20.0 μM in vitro. This compound can be used for the study of cancer and pulmonary fibrosis.
- Inhibits uridine phosphorylase (UPase).
- Increases plasma uridine concentration.
- Mitigates methotrexate-induced weight loss.
- Reduces methotrexate-induced mucosal permeability loss.
- Reduces pulmonary fibrosis in mouse models.
- For research use only.
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