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Medchemexpress LLC TL-895 | 1415823-49-2 | 99.9% | 447.50 | 50 MG
Supplier: Medchemexpress LLC HY13948150MG
TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor. It shows activity against recombinant BTK and effectively inhibits the production of inflammatory factors. This compound is used in studies of chronic lymphocytic leukemia (CLL), myelofibrosis (MF), and B-cell malignancies.
- Potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor
- Inhibits recombinant BTK (average IC50: 1.5 nM)
- Inhibits BLK, BMX, and TXK kinases
- Inhibits BTK auto-phosphorylation at the Y223 site (IC50: 1-10 nM)
- Effectively inhibits the production of inflammatory factors including IL-8, IL-1β, MCP-1, and TNF-α
- Reduces chemotactic migration of myelofibrosis cells towards SDF-1
- Used for studies of chronic lymphocytic leukemia, myelofibrosis, and B-cell malignancies
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