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Medchemexpress LLC TL02-59 | 1315330-17-6 | 99.9% | 609.64 | 1 MG
Supplier: Medchemexpress LLC HY1128521MG
TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM. It also inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. It is known to potently suppress acute myelogenous leukemia (AML) cell growth.
- Orally active, selective Src-family kinase Fgr inhibitor
- Inhibits Lyn and Hck
- Potently suppresses acute myelogenous leukemia (AML) cell growth
- Inhibits Fgr autophosphorylation in TF-1 cells
- Induces growth arrest in primary AML bone marrow samples
- Eliminates AML cells from the spleen and peripheral blood in a mouse model of AML
- Potential therapeutic agent for acute myelogenous leukemia (AML)
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