Medchemexpress LLC TL02-59 | 1315330-17-6 | 99.9% | 609.64 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY112852

TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM. It also inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. This compound potently suppresses the growth of acute myelogenous leukemia (AML) cells.

• Selectively targets the Src-family kinase Fgr with high potency (IC50 of 0.03 nM).
• Also shows inhibitory activity against Lyn (IC50 of 0.1 nM) and Hck (IC50 of 160 nM).
• Potently suppresses acute myelogenous leukemia (AML) cell growth.
• Induces growth arrest and apoptosis of AML cell lines at single-digit nM potency and induces growth arrest in primary AML bone marrow samples.
• Completely eliminates AML cells from the spleen and peripheral blood, and dramatically suppresses bone marrow involvement in a mouse model of AML.
• Has good oral bioavailability with a t1/2 of 5.7 h by i.v injection and 6.5 h by p.o. administration.

Catalog No. 50-004-39686