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Medchemexpress LLC TL13-112 | 2229037-19-6 | MFCD12922943 | 98.0% | 1002.57 | C49H60ClN9O10S | 50MG
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Supplier:  Medchemexpress LLC HY12391950MG

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TL13-112 is a small-molecule PROTAC designed to target and degrade anaplastic lymphoma kinase (ALK) in cellular models. It couples an ALK-binding warhead to a cereblon ligand to induce proteasomal degradation and has been characterized for potent ALK inhibition and cellular degradation activity in ALK-positive cancer cell lines.

  • Selective ALK PROTAC degrader that induces proteasomal degradation of ALK.
  • Potent ALK activity inhibition with IC50 = 0.14 nM.
  • Cellular ALK degradation with DC50 = 10 nM (H3122) and 40 nM (Karpas 299).
  • Also affects additional kinases including Aurora A, FER, PTK2, and RPS6KA1.
  • Molecular formula C49H60ClN9O10S and molecular weight ~1002.57 g/mol.
  • Purity reported as 98.01% by LC-MS.
  • Supplied in small milligram quantities for research use.

Catalog No. 50-002-39133


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