Medchemexpress LLC Tlr7/8/9-in-1 | 2180127-82-4 | 98.5% | 435.60 g/mol | C27H37N3O2 | 5 MG

Supplier:  Medchemexpress LLC HY1319525MG

TLR7/8/9-IN-1 is a potent, orally bioavailable small-molecule antagonist of Toll-like receptors 7, 8, and 9 used in preclinical studies to inhibit TLR signaling and downstream cytokine release. The compound is supplied as a high-purity solid with published in vitro and in vivo solubility and activity data.

• Potent antagonist activity (IC50 = 43 nM in TLR7/8/9 assays)
• Demonstrates 4.8 nM potency versus TLR7 in PBMC IL-6 reduction
• High reported purity of 98.5%
• Molecular weight 435.60 g/mol; formula C27H37N3O2
• Solid, off-white to light-yellow physical appearance
• Soluble in DMSO (83.33 mg/mL) and formulated for in vivo use (≥2.08 mg/mL)
• Suitable for preclinical studies of TLR pathway modulation

Catalog No. 50-002-62564